Bioequivalence study of buccal formulations of two prokinetic agents versus the conventional oral tablets

This study was to investigate the efficiency of buccal dosage forms to deliver poor orally absorbed drugs. Two buccal gel formulations containing two gastrokinetic drugs with low oral bioavailability; domperidone and mosapride citrate; were tested against their market products. Twenty-four volunteers were enrolled in this study divided into two groups in a single dose, two treatment and two periods cross over design. Both buccal formulations achieved high relative bioavailabilities (Frel) compared to the market products where buccal gel of domperidone achieved Frel of 202% and buccal gel of mosapride citrate achieved 162%. The study reveals the importance of the buccal route for administration of poorly absorbed drugs from the gastrointestinal tract.